"A Gifted Man" follows Michael Holt (Patrick Wilson), a brilliant and charismatic surgeon who, after his ex-wife, Anna, dies and starts to teach him the meaning of life. Thanks to his lucrative career as an exception doctor, Michel has lived the life of luxury and easiness. Michel's sister Christina (Julie Benz), a single mother to a teenaged son, Milo (Liam Aiken), is happy that Anna is back in her brother's life even though she is only an illusion. Michael was always a better person because of her. However, Rita (Margo Martindale) is concerned of Michael's sudden change in behavior.