The Big Bang Theory is a comedy series about four young scientists who know all about the world of physics, and one girl, who gives the physics world a real spin.

"Man Up" is about three men who try to reignite the tough guy in them and what it takes to be the "real man" as Will (Mather Zickel), who is married to Theresa (Teri Polo), wants to find out what it takes to bring out the "real man" inside. Being a man in these times has changed and Will is focused only on getting his son Nathan (Jake Johnson) the perfect gift for his 13th birthday. While Craig (Christopher Moynihan) still has feelings for his college ex-girlfriend Lisa, Kenny (Dan Fogler) suppresses his anger towards his ex-wife Brenda (Amanda Detmer) by saying, "What would Tobey Maguire do? When Brenda starts dating a new guy (Henry Simmons), Kenny has to try even harder.

Monica is reluctant to introduce her new boyfriend, Alan, to her friends because they've mocked all of the boyfriend they've met before. To her surprise, they love Alan.

Rose goes off on her first adventure with the Doctor who takes her 5 billion years into the future to view a cataclysmic event: the destruction of the Earth.

What happens to nature after a nuclear accident? And how does wildlife deal with the world it inherits after human inhabitants have fled?